Wu L, Pierce G F, Ladin D A, Zhao L L, Rogers D, Mustoe T A
Division of Plastic Surgery, Northwestern University Medical School, Chicago, IL 60611, USA.
Growth Factors. 1995;12(1):29-35. doi: 10.3109/08977199509003211.
Kaposi's fibroblast growth factor (K-FGF, FGF-4) is a newer member of FGF family with uncharacterized wound healing properties. Basic fibroblast growth factor (bFGF, FGF-2) has been well studied and accelerates repair in normal and impaired wound healing models. K-FGF and bFGF are known to have similar biological effects in tissue culture, and both stimulate fibroblast and endothelial cell proliferation. The rabbit dermal ulcer model was used to examine the effects of bFGF and K-FGF under ischemic and nonischemic conditions. We found bFGF was ineffective in stimulating healing under ischemic conditions even at high doses (30 micrograms/wound). However, when the ischemic wounds were treated with bFGF (5 micrograms/wound) plus hyperbaric oxygen therapy, it was highly effective again as previously found under nonischemic conditions (P < 0.05). In contrast K-FGF stimulated repair in both nonischemic and ischemic wounds (P < 0.05). These results suggest that wound oxygen content differentially regulates responsiveness to bFGF and that K-FGF is biologically active in hypoxic wounds.
卡波西成纤维细胞生长因子（K-FGF，FGF-4）是成纤维细胞生长因子家族的一个新成员，其伤口愈合特性尚不明确。碱性成纤维细胞生长因子（bFGF，FGF-2）已得到充分研究，在正常和受损伤口愈合模型中均可加速修复。已知K-FGF和bFGF在组织培养中具有相似的生物学效应，二者均可刺激成纤维细胞和内皮细胞增殖。本研究采用兔皮肤溃疡模型，观察bFGF和K-FGF在缺血和非缺血条件下的作用。我们发现，即使高剂量使用bFGF（30微克/伤口），在缺血条件下刺激愈合仍无效。然而，当缺血伤口接受bFGF（5微克/伤口）加高压氧治疗时，其效果与先前在非缺血条件下观察到的一样显著（P < 0.05）。相比之下，K-FGF在非缺血和缺血伤口中均能刺激修复（P < 0.05）。这些结果表明，伤口氧含量对bFGF反应性具有不同调节作用，且K-FGF在缺氧伤口中具有生物学活性。
