确定吸入过程中可感知的乳糖药物载体的最小剂量。
Determination of the minimum dose of lactose drug carrier that can be sensed during inhalation.
作者信息
Higham M A, Sharara A M, Magee R P, Ind P W
机构信息
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Br J Clin Pharmacol. 1995 Sep;40(3):281-2. doi: 10.1111/j.1365-2125.1995.tb05786.x.
Lactose is commonly used as a carrier for inhaled drugs. Twenty healthy volunteers without respiratory symptoms inhaled seven different doses of lactose and a placebo (empty) dose through the four place Diskhaler device, in order to determine the lowest dose that could be reliably sensed. The minimum dose for which all subjects reported taste or feel sensations was 10 mg. This has implications regarding the amount of carrier used in future drug delivery systems.
乳糖通常用作吸入药物的载体。20名无呼吸道症状的健康志愿者通过四孔Diskhaler装置吸入七种不同剂量的乳糖和一剂安慰剂（空剂量），以确定能够可靠感知的最低剂量。所有受试者报告有味道或感觉的最低剂量为10毫克。这对未来药物递送系统中载体的用量有影响。
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