在视网膜母细胞瘤细胞系中扩增的线粒体ATP合酶α亚基基因定位于18号染色体。

Mitochondrial ATP synthase alpha-subunit gene amplified in a retinoblastoma cell line maps to chromosome 18.

作者信息

Bie W, Squire J A, Fraser M, Paterson M C, Godbout R

机构信息

Molecular Oncology Program, Cross Cancer Institute, Edmonton, Alberta, Canada.

出版信息

Genes Chromosomes Cancer. 1995 Sep;14(1):63-7. doi: 10.1002/gcc.2870140111.

DOI:10.1002/gcc.2870140111

PMID:8527386

Abstract

The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DDXI. Both genes have been mapped to chromosome band 2p24. A third gene, encoding the alpha-subunit of mitochondrial ATP synthase (ATPSA), is also amplified in Y79. Here we report that there are at least four human mitochondrial ATPSA-related genes located on four different chromosomes. The ATPSA gene that is amplified in Y79 originates from chromosome 18. In Y79, the amplified copies of both the ATPSA and the MYCN genes are located on a homogeneously staining region (HSR) at chromosome band Ip34.

摘要

人视网膜母细胞瘤细胞系Y79含有多个MYCN基因拷贝和DEAD框基因DDXI。这两个基因都已定位到染色体2p24带。第三个基因，编码线粒体ATP合酶（ATPSA）的α亚基，在Y79中也有扩增。在此我们报告，至少有四个与人类线粒体ATPSA相关的基因位于四条不同的染色体上。在Y79中扩增的ATPSA基因起源于18号染色体。在Y79中，ATPSA和MYCN基因的扩增拷贝都位于染色体1p34带的一个均匀染色区（HSR）上。