Pichot W, Hansenne M, Gonzalez Moreno A, Ansseau M
Psychiatric Unit, University Hospital of Liège, Belgium.
Eur Arch Psychiatry Clin Neurosci. 1995;245(6):306-8. doi: 10.1007/BF02191872.
Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 male drug-free inpatients meeting Research Diagnostic Criteria for panic disorder who were compared with 10 male major depressive inpatients and 10 male normal controls. The three groups differed significantly in the GH peak response (mean +/- SD): 27.8 +/- 12.5 ng/ml in panics, 5.4 +/- 4.0 ng/ml in major depressives, and 25.8 +/- 11.3 ng/ml in normal controls (F(2,27) = 15.3; P = 0.00003). Although there were significant differences between panics and major depressives (P = 0.00004), and between major depressives and controls (P = 0.00004), panics did not significantly differ from controls. These results do not support the hypothesis of an overlap between panic and affective disorders, and suggest that the hypothalamo-GH-somatomedin axis could be intact in panic disorder.
多项证据表明多巴胺可能与焦虑状态有关。在本研究中，我们评估了10名符合惊恐障碍研究诊断标准的未服用药物的男性住院患者对0.5毫克阿扑吗啡（一种多巴胺能激动剂）的生长激素（GH）反应，并将其与10名男性重度抑郁住院患者和10名男性正常对照进行比较。三组在GH峰值反应（均值±标准差）上有显著差异：惊恐障碍患者为27.8±12.5纳克/毫升，重度抑郁患者为5.4±4.0纳克/毫升，正常对照为25.8±11.3纳克/毫升（F(2,27)=15.3；P=0.00003）。尽管惊恐障碍患者与重度抑郁患者之间（P=0.00004）以及重度抑郁患者与对照组之间（P=0.00004）存在显著差异，但惊恐障碍患者与对照组之间无显著差异。这些结果不支持惊恐障碍与情感障碍重叠的假说，并表明下丘脑 - GH - 生长调节素轴在惊恐障碍中可能是完整的。
