Schittecatte M, Charles G, Machowski R, Wilmotte J
Department of Psychiatry, Vincent Van Gogh Hospital, Marchienne-Au-Pont, Belgium.
Br J Psychiatry. 1989 Jun;154:858-63. doi: 10.1192/bjp.154.6.858.
We have observed a significantly higher growth hormone (GH) response to clonidine administration (150 micrograms i.v.) in 14 patients with a major depressive disorder who had never received antidepressant therapy than in 14 matched depressive patients who had not received tricyclic drugs for at least 15 days. Compared with a control group of eight subjects, untreated depressed patients, as a group, had a normal response, while matched patients had markedly blunted response. Results for the group of untreated depressed patients showed that some patients had a blunted response while others had a response in the normal range. The results suggest that studies on the GH response to clonidine in psychiatric patients need to take into account the confounding and long-lasting effects of tricyclics.
我们观察到，14名从未接受过抗抑郁治疗的重度抑郁症患者对可乐定静脉注射（150微克）的生长激素（GH）反应，显著高于14名匹配的、至少15天未服用三环类药物的抑郁症患者。与8名受试者组成的对照组相比，未经治疗的抑郁症患者作为一个整体，反应正常，而匹配患者的反应明显减弱。未经治疗的抑郁症患者组的结果显示，一些患者反应减弱，而另一些患者的反应在正常范围内。结果表明，在精神科患者中研究GH对可乐定的反应时，需要考虑三环类药物的混杂和长期影响。
