烟酰胺腺嘌呤二核苷酸糖水解酶与环磷酸腺苷核糖的代谢
NAD glycohydrolases and the metabolism of cyclic ADP-ribose.
作者信息
Jacobson M K, Cervantes-Laurean D, Strohm M S, Coyle D L, Bummer P M, Jacobson E L
机构信息
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 76107, USA.
出版信息
Biochimie. 1995;77(5):341-4. doi: 10.1016/0300-9084(96)88144-2.
PMID:8527487
Abstract
Cyclic ADP-ribose is a recently discovered metabolite of NAD that functions in cellular calcium signalling. The discovery that NAD glycohydrolases can catalyze the synthesis and hydrolysis of cyclic ADP-ribose has renewed interest in this class of ADP-ribose transferring enzymes that were discovered over 50 years ago.
摘要
环磷酸腺苷核糖是一种最近发现的烟酰胺腺嘌呤二核苷酸（NAD）代谢产物，在细胞钙信号传导中发挥作用。烟酰胺腺嘌呤二核苷酸糖水解酶能够催化环磷酸腺苷核糖的合成与水解，这一发现重新引发了人们对这类在50多年前就已被发现的ADP核糖转移酶的兴趣。
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