鹅去氧胆酸钠对人旷置结肠草酸吸收的影响——“肠源性”高草酸尿症的一种机制
Effect of sodium chenodeoxycholate on oxalate absorption from the excluded human colon--a mechanism for 'enteric' hyperoxaluria.
作者信息
Fairclough P D, Feest T G, Chadwick V S, Clark M L
出版信息
Gut. 1977 Mar;18(3):240-4. doi: 10.1136/gut.18.3.240.
Abstract
A perfusion technique has been used to study the effect of sodium chenodeoxycholate (5 mmol 1-1) on absorption of oxalate (2 mmol 1-1) from the surgically excluded colon in two patients with chronic liver disease. Colonic absorption of oxalate increased at least fivefold when sodium chenodeoxycholate was incorporated in the perfusion solutions. This observation may explain enteric hyperoxaluria after ileal resection and in some other gastrointestinal disorders.
摘要
采用灌注技术研究了鹅去氧胆酸钠（5毫摩尔/升）对两名慢性肝病患者手术切除结肠中草酸盐（2毫摩尔/升）吸收的影响。当灌注液中加入鹅去氧胆酸钠时，结肠对草酸盐的吸收至少增加了五倍。这一观察结果可能解释了回肠切除术后及其他一些胃肠道疾病中的肠道高草酸尿症。
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Effect of sodium chenodeoxycholate on oxalate absorption from the excluded human colon--a mechanism for 'enteric' hyperoxaluria.鹅去氧胆酸钠对人旷置结肠草酸吸收的影响——“肠源性”高草酸尿症的一种机制
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本文引用的文献
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Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride.胆汁酸吸收不良在回肠切除患者腹泻和脂肪泻发病机制中的作用。I. 对消胆胺的反应或用中链甘油三酯替代膳食长链甘油三酯。
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