Wang J T, Wang T H, Lin J T, Lee C Z, Sheu J C, Chen D S
Department of Bacteriology, College of Medicine, National Taiwan University, Taipei.
J Gastroenterol Hepatol. 1995 Jul-Aug;10(4):454-8. doi: 10.1111/j.1440-1746.1995.tb01599.x.
A national screening programme for antibody to hepatitis C virus (HCV) in blood donors in Taiwan began in July 1992 using a second-generation immunoassay. To study the impact of this screening on post-transfusion hepatitis in Taiwan, a prospective study on post-transfusion hepatitis, that was started in 1987, was continued. As of June 1994, 245 patients who received a blood transfusion after July 1992 had completed a follow-up period for more than 6 months post-transfusion. Of them, seven (2.8%) recipients developed acute post-transfusion hepatitis. The hepatitis in six cases could not be attributed to infection by hepatitis A, B, C, D, E viruses or cytomegalovirus (CMV) or Epstein-Barr virus (EBV). The remaining patient seroconverted to both IgG and IgM anti-CMV. All seven patients recovered in 6 months without development of chronicity, and the mean peak alanine aminotransferase level was lower compared with that of the cases before anti-HCV screening (i.e. pre-July 1992). These results indicate that the current anti-HCV screening has effectively interrupted HCV transmission through blood transfusion in Taiwan.
台湾于1992年7月开始采用第二代免疫分析法对献血者进行丙型肝炎病毒（HCV）抗体筛查。为研究此项筛查对台湾输血后肝炎的影响，对始于1987年的输血后肝炎前瞻性研究继续进行。截至1994年6月，245例在1992年7月后接受输血的患者完成了输血后6个月以上的随访期。其中，7例（2.8%）受血者发生了急性输血后肝炎。6例肝炎病例无法归因于甲型、乙型、丙型、丁型、戊型肝炎病毒或巨细胞病毒（CMV）或EB病毒（EBV）感染。其余1例患者CMV IgG和IgM均发生血清学转换。所有7例患者均在6个月内康复，未发展为慢性肝炎，与抗HCV筛查前（即1992年7月前）的病例相比，平均谷丙转氨酶峰值水平较低。这些结果表明，目前的抗HCV筛查已有效阻断了台湾地区通过输血传播HCV的途径。
