Grant D S, Rose R W, Kinsella J K, Kibbey M C
Cardeza Foundation for Hematological Research, Thomas Jefferson University, College of Medicine, Philadelphia, PA 19107, USA.
EXS. 1995;74:235-48. doi: 10.1007/978-3-0348-9070-0_12.
Here we review the role of angiogenesis as it pertains to the interactions between the epithelium and the mesenchyme, especially during tumor growth and metastasis. We illustrate and discuss several models of angiogenesis including endothelial tube formation on Matrigel. Finally, we examine angiogenic factors using the Matrigel model and investigate several other matrix molecules for their importance in angiogenesis and epithelial/stromal interactions.
在此，我们回顾血管生成在上皮与间充质相互作用中所起的作用，尤其是在肿瘤生长和转移过程中的作用。我们举例说明并讨论了几种血管生成模型，包括在基质胶上形成内皮管。最后，我们使用基质胶模型研究血管生成因子，并研究其他几种基质分子在血管生成和上皮/基质相互作用中的重要性。
