de Vries J D
Department of Pediatric Urology, University Hospital of Nijmegen, The Netherlands.
World J Urol. 1995;13(4):219-25. doi: 10.1007/BF00182966.
Even though rhabdomyosarcoma is the most common soft tissue sarcoma in children, accounting for 5-10% of all malignant disease in children under 15 years of age, so few cases are seen in a single institution that only the combined efforts of multicentre prospective trials made it possible fro adequate treatment schedules to be devised. Thank to this cooperation, survival rates have increased dramatically in recent decades; risk factors have been identified and treatment can now be adapted accordingly. This is especially true for the paratesticular rhabdomyosarcoma (PTRM), which now has a good prognosis in all stages. The striking similarity of tumor behavior and metastatic pathways to those in germ-cell tumors in young male adults can provide us with more extensive data derived from a much larger group of patients. Recent data are gathered and evaluated in this review. Only in this way will it be possible to eliminate all treatment modalities known to be followed by severe sequelae, thus avoiding exposure of the patients to a therapy that carries more risks than the primary tumor itself.
尽管横纹肌肉瘤是儿童最常见的软组织肉瘤，占15岁以下儿童所有恶性疾病的5% - 10%，但在单个机构中见到的病例极少，以至于只有通过多中心前瞻性试验的共同努力，才有可能制定出足够的治疗方案。由于这种合作，近几十年来生存率大幅提高；已确定了风险因素，现在治疗可以据此进行调整。对于睾丸旁横纹肌肉瘤（PTRM）尤其如此，其目前在所有阶段都有良好的预后。肿瘤行为和转移途径与年轻成年男性生殖细胞肿瘤的显著相似性，可以为我们提供来自更大患者群体的更广泛数据。本综述收集并评估了近期数据。只有这样，才有可能消除所有已知会伴有严重后遗症的治疗方式，从而避免让患者接受比原发性肿瘤本身风险更高的治疗。
