Stief C G, Weller E, Noack T, Djamilian M, Meschi M, Truss M, Jonas U
Department of Urology, Medizinische Hochschule Hannover, Germany.
World J Urol. 1995;13(4):243-7. doi: 10.1007/BF00182971.
Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with smooth-muscle degeneration due to partial denervation. Our study was done to evaluate the possible beneficial effect of transcutaneously applied low-frequency electric current on the corpus cavernosum penis in the treatment of erectile dysfunction. After a comprehensive workup, 21 patients with chronic erectile dysfunction (20/21 vasoactive nonresponders) received daily (3-5 x 20 min) transcutaneous functional electromyostimulation of the corpus cavernosum smooth muscles [FEMCC; zero-line symmetric impulses of trapezoid shape, 2-channel device with alternating stimulations; frequency (f), 10-20 Hz for channel I and 20-35 Hz for channel II; impulse duration (ti), 100-150 microseconds; approx. 12 mA; rise time, 0.5 s; stimulation time, 5 s/channel; pause between stimulations, 0.5 s. In all, 4/21 patients (19%) regained full spontaneous erections and another 3/21 (14%) responded to vasoactive drugs after FEMCC. Overall, 14/21 were FEMCC failures, including 2 who subjectively "improved." In a similar group of patients who were evaluated during the same period but received no therapy, no spontaneous improvement in erectile function was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
经皮应用低频电流治疗部分或暂时失神经支配的横纹肌，被广泛用于预防或治疗肌肉萎缩。由于平滑肌细胞具有较高的再生能力，这种方法对于治疗因部分失神经支配导致平滑肌变性的疾病应该是有益的。我们开展这项研究是为了评估经皮应用低频电流对阴茎海绵体治疗勃起功能障碍可能产生的有益效果。经过全面检查，21例慢性勃起功能障碍患者（20/21例对血管活性药物无反应者）接受了阴茎海绵体平滑肌的每日经皮功能性肌电刺激[FEMCC；梯形零基线对称脉冲，2通道交替刺激装置；频率（f），通道I为10 - 20Hz，通道II为20 - 35Hz；脉冲持续时间（ti），100 - 150微秒；约12mA；上升时间，0.5秒；刺激时间，每通道5秒；刺激间隔，0.5秒。总共，4/21例患者（19%）恢复了完全自发勃起，另外3/21例（14%）在接受FEMCC后对血管活性药物有反应。总体而言，14/21例为FEMCC治疗失败，其中2例主观上“有所改善”。在同期评估的一组未接受治疗的类似患者中，未观察到勃起功能的自发改善。（摘要截断于250字）
