Roche R J, Moxon E R
Dept of Paediatrics, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Trends Microbiol. 1995 Aug;3(8):304-9. doi: 10.1016/s0966-842x(00)88959-3.
Phenotypic variation of two major carbohydrate surface antigens of Haemophilus influenzae, the capsule and lipopolysaccharide, exemplifies some of the genetic mechanisms used by pathogenic bacteria in interacting with host microenvironments. The ability to generate phenotypic variety at high frequency within clonal populations of microorganisms provides an adaptive mechanism to combat the polymorphisms and immune repertoires of the host.
流感嗜血杆菌的两种主要碳水化合物表面抗原（荚膜和脂多糖）的表型变异，例证了病原菌在与宿主微环境相互作用中所采用的一些遗传机制。在微生物的克隆群体中高频产生表型多样性的能力，提供了一种对抗宿主多态性和免疫库的适应性机制。
