烟曲霉毒力决定因素的研究
The search for virulence determinants in Aspergillus fumigatus.
作者信息
Bouchara J P, Tronchin G, Larcher G, Chabasse D
机构信息
Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Angers, France.
出版信息
Trends Microbiol. 1995 Aug;3(8):327-30. doi: 10.1016/s0966-842x(00)88965-9.
PMID:8528619
Abstract
The development of aspergillosis in an immunodeficient host depends on interactions between fungal and host components. The recognition by Aspergillus fumigatus of fibrinogen and laminin, and the secretion of extracellular proteinases and ribonucleotoxin have been suggested to mediate adherence to mucosal surfaces and subsequently to bring about host-tissue invasion.
摘要
免疫缺陷宿主中曲霉菌病的发展取决于真菌与宿主成分之间的相互作用。据推测，烟曲霉对纤维蛋白原和层粘连蛋白的识别，以及细胞外蛋白酶和核糖核酸毒素的分泌，介导了其对粘膜表面的粘附，随后导致宿主组织侵袭。
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