Heyman S N, Kaminski N, Brezis M
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Exp Nephrol. 1995 Nov-Dec;3(6):331-7.
The effects of dopamine (10 micrograms/kg/min i.v.) upon intrarenal microcirculation, total, superficial cortical and outer medullary blood flows and outer medullary pO2 were continuously determined in anesthetized rats with ultrasonic and laser-Doppler probes and oxygen microelectrodes. While total and cortical flows were unaffected, outer medullary flow increased by 35 +/- 5% (mean +/- SE, p < 0.01). Outer medullary pO2 was not significantly altered (from 16 +/- 4 to 18 +/- 4 mm Hg). In volume-expanded rats total and cortical flows rose as well. In rats pretreated with indomethacin, with or without N omega-nitro-L-arginine methyl ester HCl, dopamine restored renal microcirculation and ameliorated outer medullary hypoxia.
用超声和激光多普勒探头以及氧微电极在麻醉大鼠中连续测定多巴胺（静脉注射，10微克/千克/分钟）对肾内微循环、总血流量、浅表皮质血流量、外髓血流量和外髓pO₂的影响。虽然总血流量和皮质血流量未受影响，但外髓血流量增加了35±5%（平均值±标准误，p<0.01）。外髓pO₂没有显著改变（从16±4毫米汞柱变为18±4毫米汞柱）。在血容量扩充的大鼠中，总血流量和皮质血流量也增加。在用吲哚美辛预处理的大鼠中，无论是否使用盐酸N-ω-硝基-L-精氨酸甲酯，多巴胺都能恢复肾微循环并改善外髓缺氧。
