具有天然特性且结构明确的设计α-螺旋束。
Native-like and structurally characterized designed alpha-helical bundles.
作者信息
Betz S F, Bryson J W, DeGrado W F
机构信息
DuPont Merck Pharmaceutical Company, Wilmington, USA.
出版信息
Curr Opin Struct Biol. 1995 Aug;5(4):457-63. doi: 10.1016/0959-440x(95)80029-8.
PMID:8528761
Abstract
A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.
摘要
最近已经设计出了许多卷曲螺旋和α-螺旋束，现在许多已通过X射线晶体学进行了结构表征。其他一些虽然在结构上没有得到很好的表征，但在水溶液中表现出类似天然的性质。这两个研究领域都为我们理解这类分子的特异性本质做出了巨大贡献。
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