Montano N, Barman S M, Gnecchi-Ruscone T, Porta A, Lombardi F, Malliani A
Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale L Sacco, Università degli Studi, Milano.
Cardiologia. 1995 Jan;40(1):41-6.
We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.
我们记录了27只压力感受器去神经支配的去大脑猫中位于延髓头端腹外侧(n = 21)、外侧被盖区(n = 10)和尾侧中缝核(n = 14)的45个单神经元的放电活动。对神经元活动和收缩期动脉压(SAP)进行了自回归谱分析。记录的神经元放电与交感神经放电中出现的2至6Hz振荡或10Hz节律相关。在25个(55%)单位中观察到低频(LF)振荡(0.12±0.02Hz)。在45个记录中的25个(55%)中，SAP变异性中发现了相同的节律性。在其中21例中，SAP变异性中的LF与神经活动中的LF高度相关。此外，45个神经元中的32个(71%)显示出与通气率相关的较高节律(HF;0.34±0.06Hz)。这些数据证明了单个延髓神经元放电中存在LF振荡，参与心血管系统的调节。这个LF成分与在SAP变异性谱分析中可检测到的成分相似，从而支持了这种节律主要独立于压力感受器输入的中枢起源假说。
