Martel F L, Nevison C M, Simpson M J, Keverne E B
Sub-Department of Animal Behaviour, University of Cambridge, England.
Dev Psychobiol. 1995 Mar;28(2):71-84. doi: 10.1002/dev.420280202.
Rhesus monkeys of 9 weeks, 48 weeks, 100 weeks, 150 weeks of age (young subjects), or mature parous females that were not lactating were given acute single doses of the opioid antagonist naloxone (0.5 mg/kg) and vehicle on different days and observed in their familial social groups. Naloxone increased the occurrence of affiliative behaviours. Young subjects spent more time in contact with their mothers but showed no changes in social grooming. Maternal contact was actively sought through contact vocalizations, decreasing proximity, and, for the youngest infants, increased attempts to suckle. Mature females made more solicitations for grooming and received more grooming from their companions. These results are interpreted in terms of naloxone blocking the positive effect arising from social contact and thus causing subjects to seek further affiliative comfort.
对9周、48周、100周、150周龄的恒河猴（幼年个体）或未处于哺乳期的成熟经产雌性恒河猴，在不同日期给予急性单次剂量的阿片类拮抗剂纳洛酮（0.5毫克/千克）和赋形剂，并在其家族社会群体中进行观察。纳洛酮增加了亲和行为的发生率。幼年个体与母亲接触的时间增多，但社会梳理行为没有变化。通过接触叫声、缩短距离积极寻求与母亲接触，对于最年幼的幼猴，还增加了吸吮尝试。成熟雌性更多地主动寻求梳理，并从同伴那里得到更多的梳理。这些结果被解释为纳洛酮阻断了社会接触产生的积极作用，从而使个体寻求更多的亲和安慰。
