在新西兰兔眼部模型中，表达1型单纯疱疹病毒潜伏相关转录物的三叉神经节神经元比例与病毒再激活相关。 - Suppr

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超能文献

The proportion of trigeminal ganglionic neurons expressing herpes simplex virus type 1 latency-associated transcripts correlates to reactivation in the New Zealand rabbit ocular model.

作者信息

Gordon Y J, Romanowski E G, Araullo-Cruz T, Kinchington P R

机构信息

Eye & Ear Institute of Pittsburgh, PA 15213, USA.

出版信息

Graefes Arch Clin Exp Ophthalmol. 1995 Oct;233(10):649-54. doi: 10.1007/BF00185286.

DOI:10.1007/BF00185286

PMID:8529909

Abstract

摘要

相似文献

The proportion of trigeminal ganglionic neurons expressing herpes simplex virus type 1 latency-associated transcripts correlates to reactivation in the New Zealand rabbit ocular model.在新西兰兔眼部模型中，表达1型单纯疱疹病毒潜伏相关转录物的三叉神经节神经元比例与病毒再激活相关。

Graefes Arch Clin Exp Ophthalmol. 1995 Oct;233(10):649-54. doi: 10.1007/BF00185286.

A thymidine kinase deficient HSV-2 strain causes acute keratitis and establishes trigeminal ganglionic latency, but poorly reactivates in vivo.一种胸苷激酶缺陷型单纯疱疹病毒2型毒株可引起急性角膜炎并建立三叉神经节潜伏感染，但在体内再激活能力较差。

J Med Virol. 1994 Jul;43(3):297-309. doi: 10.1002/jmv.1890430319.

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.单纯疱疹病毒潜伏相关转录本可阻断病毒诱导的神经元凋亡。

Science. 2000 Feb 25;287(5457):1500-3. doi: 10.1126/science.287.5457.1500.

The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.1型单纯疱疹病毒在体内重新激活的概率会随着神经节中潜伏感染神经元数量的增加而上升。

J Virol. 1998 Aug;72(8):6888-92. doi: 10.1128/JVI.72.8.6888-6892.1998.

A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels.一种能够阻断细胞凋亡的基因可替代1型单纯疱疹病毒潜伏相关转录基因，并恢复野生型再激活水平。

J Virol. 2002 Feb;76(3):1224-35. doi: 10.1128/jvi.76.3.1224-1235.2002.

Nerve growth factor antibody stimulates reactivation of ocular herpes simplex virus type 1 in latently infected rabbits.神经生长因子抗体可刺激潜伏感染兔的单纯疱疹病毒1型眼部再激活。

J Neurovirol. 1997 Jun;3(3):206-11. doi: 10.3109/13550289709018295.

Severity of experimentally reactivated herpetic eye disease is related to the neurovirulence of the latent virus.实验性重新激活的疱疹性眼病的严重程度与潜伏病毒的神经毒性有关。

Invest Ophthalmol Vis Sci. 1987 Feb;28(2):229-37.

Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia.1型单纯疱疹病毒潜伏感染再激活率与三叉神经节中受感染神经元数量之间的相关性。

Virology. 1996 Nov 1;225(1):72-81. doi: 10.1006/viro.1996.0576.

An M2 Rather than a T2 Response Contributes to Better Protection against Latency Reactivation following Ocular Infection of Naive Mice with a Recombinant Herpes Simplex Virus 1 Expressing Murine Interleukin-4.一种 M2 反应而非 T2 反应有助于更好地保护未感染的小鼠免受潜伏性再激活，方法是用表达鼠白细胞介素-4 的重组单纯疱疹病毒 1 眼部感染。

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Localization of 3H-thymidine-labeled HSV-1 in latently infected rabbit trigeminal ganglion cells.

Invest Ophthalmol Vis Sci. 1987 Feb;28(2):394-7.

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EMBO Rep. 2021 Sep 6;22(9):e52547. doi: 10.15252/embr.202152547. Epub 2021 Jul 1.

Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2.单纯疱疹病毒1型潜伏相关转录本（LAT）阴性突变体dLAT2903的神经毒性增加及再激活，其LAT miR-H2被破坏

J Neurovirol. 2016 Feb;22(1):38-49. doi: 10.1007/s13365-015-0362-y. Epub 2015 Jun 12.

HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons.单纯疱疹病毒 1 基因组亚核定位及其与宿主细胞 PML-NBs 和着丝粒的关联，在神经元潜伏期间调节潜伏相关转录物（LAT）基因座的转录。

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Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival.单纯疱疹病毒1型潜伏相关转录基因促进神经元存活。

J Virol. 2001 Jul;75(14):6660-75. doi: 10.1128/JVI.75.14.6660-6675.2001.

J Virol. 1998 Aug;72(8):6888-92. doi: 10.1128/JVI.72.8.6888-6892.1998.

The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation.个体神经元中潜伏的1型单纯疱疹病毒基因组拷贝数具有病毒株特异性，且与病毒激活相关。

J Virol. 1998 Jul;72(7):5343-50. doi: 10.1128/JVI.72.7.5343-5350.1998.

本文引用的文献

Reactivation in vivo and in vitro of herpes simplex virus from mouse dorsal root ganglia which contain different levels of latency-associated transcripts.从小鼠背根神经节中重新激活体内和体外单纯疱疹病毒，这些神经节含有不同水平的潜伏相关转录本。

J Gen Virol. 1993 Jun;74 ( Pt 6):995-1002. doi: 10.1099/0022-1317-74-6-995.

Neurons containing latency-associated transcripts are numerous and widespread in dorsal root ganglia following footpad inoculation of mice with herpes simplex virus type 1 mutant in1814.在用1814单纯疱疹病毒1型突变株对小鼠进行足垫接种后，背根神经节中含有潜伏相关转录本的神经元数量众多且分布广泛。

J Gen Virol. 1993 Jun;74 ( Pt 6):985-94. doi: 10.1099/0022-1317-74-6-985.

In-situ polymerase chain reaction. An overview of methods, applications and limitations of a new molecular technique.原位聚合酶链反应。一种新分子技术的方法、应用及局限性概述。

Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(2):67-73.

Quantity of latency-associated transcript produced by herpes simplex virus is not predictive of the frequency of experimental recurrent genital herpes.单纯疱疹病毒产生的潜伏相关转录物的量不能预测实验性复发性生殖器疱疹的频率。

J Infect Dis. 1994 May;169(5):1084-7. doi: 10.1093/infdis/169.5.1084.

Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain.大鼠脑潜伏感染细胞中单纯疱疹病毒1型DNA和潜伏相关转录RNA的竞争性定量PCR分析。

J Virol. 1994 Mar;68(3):1864-73. doi: 10.1128/JVI.68.3.1864-1873.1994.

Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo.肾上腺素诱导潜伏感染兔体内单纯疱疹病毒1型再激活过程中的分子分析

J Virol. 1994 Mar;68(3):1283-92. doi: 10.1128/JVI.68.3.1283-1292.1994.

Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia.单纯疱疹病毒1型在潜伏感染的小鼠感觉神经节外植体诱导再激活过程中的DNA复制和基因表达。

J Virol. 1994 Mar;68(3):1271-82. doi: 10.1128/JVI.68.3.1271-1282.1994.

HSV-1 shedding by lontophoresis of 6-hydroxydopamine followed by topical epinephrine.通过6-羟基多巴胺电离子导入法继以局部应用肾上腺素来实现单纯疱疹病毒1型脱落。

Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1588-94.

Detection of HSV-1 genome in central nervous system of latently infected mice.潜伏感染小鼠中枢神经系统中单纯疱疹病毒1型基因组的检测

Nature. 1983 Apr 7;302(5908):523-5. doi: 10.1038/302523a0.

Recovery of herpes simplex virus from human sacral ganglions.从人骶神经节中分离出单纯疱疹病毒。

N Engl J Med. 1974 Oct 17;291(16):828-30. doi: 10.1056/NEJM197410172911606.

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