1型单纯疱疹病毒在体内重新激活的概率会随着神经节中潜伏感染神经元数量的增加而上升。
The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.
作者信息
Sawtell N M
机构信息
Division of Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.
出版信息
J Virol. 1998 Aug;72(8):6888-92. doi: 10.1128/JVI.72.8.6888-6892.1998.
Abstract
The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P < 0. 0001 [Pearson correlation]).
摘要
本研究的目的是确定单纯疱疹病毒（HSV）潜伏与体内神经节再激活之间的关系。通过改变野生型1型单纯疱疹病毒17syn +株的输入滴度，生成了潜伏感染神经元数量在1.9%至24%之间的小鼠组。通过热应激诱导每组小鼠体内病毒的再激活。在所检查的整个范围内，表现出病毒再激活的动物数量与神经节中潜伏感染神经元的数量呈正相关（r = 0.9852，P < 0.0001[Pearson相关性]）。
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本文引用的文献
1
The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation.个体神经元中潜伏的1型单纯疱疹病毒基因组拷贝数具有病毒株特异性，且与病毒激活相关。
J Virol. 1998 Jul;72(7):5343-50. doi: 10.1128/JVI.72.7.5343-5350.1998.
2
Dynamics of pseudorabies virus infections in vaccinated pig populations: a review.接种疫苗的猪群中伪狂犬病病毒感染的动态：综述
Vet Q. 1997 Sep;19(3):117-22. doi: 10.1080/01652176.1997.9694754.
3
Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.单纯疱疹病毒2型潜伏相关转录物（LAT）启动子5'端的突变影响体内LAT的表达，但不影响生殖器疱疹的自发再激活率。
J Virol. 1997 Oct;71(10):7903-10. doi: 10.1128/JVI.71.10.7903-7910.1997.
4
A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.潜伏期相关转录物启动子起始处的一个437个碱基对的缺失显著降低了潜伏感染兔子中肾上腺素诱导的单纯疱疹病毒1型眼部再激活。
J Virol. 1997 Sep;71(9):6555-9. doi: 10.1128/JVI.71.9.6555-6559.1997.
5
The role of biotechnologically engineered vaccines and diagnostics in pseudorabies (Aujeszky's disease) eradication strategies.生物技术工程疫苗和诊断方法在伪狂犬病（奥耶斯基氏病）根除策略中的作用。
Vet Microbiol. 1997 Apr;55(1-4):49-60. doi: 10.1016/s0378-1135(96)01306-5.
6
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.单纯疱疹病毒1型潜伏相关转录基因调控潜伏状态的建立。
J Virol. 1997 Jul;71(7):5432-40. doi: 10.1128/JVI.71.7.5432-5440.1997.
7
Comprehensive quantification of herpes simplex virus latency at the single-cell level.在单细胞水平对单纯疱疹病毒潜伏状态进行全面定量分析。
J Virol. 1997 Jul;71(7):5423-31. doi: 10.1128/JVI.71.7.5423-5431.1997.
8
Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia.1型单纯疱疹病毒潜伏感染再激活率与三叉神经节中受感染神经元数量之间的相关性。
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J Gen Virol. 1996 Oct;77 ( Pt 10):2583-90. doi: 10.1099/0022-1317-77-10-2583.
10
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