唾液酸黏附素（Sn）定位于小鼠的2号染色体和人类的20号染色体，且与唾液酸黏附素家族的其他成员CD22、髓鞘相关糖蛋白（MAG）和CD33没有连锁关系。

Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33.

作者信息

Mucklow S, Hartnell A, Mattei M G, Gordon S, Crocker P R

机构信息

Imperial Cancer Research Fund Molecular Haemopoiesis Laboratory, Institute of Molecular Medicine, University of Oxford, United Kingdom.

出版信息

Genomics. 1995 Jul 20;28(2):344-6. doi: 10.1006/geno.1995.1153.

DOI:10.1006/geno.1995.1153

PMID:8530048

Abstract

Sialoadhesin is a cell-cell interaction molecule expressed by subpopulations of tissue macrophages. It contains 17 immunoglobulin (Ig)-like domains and is structurally related to CD22, MAG, and CD33. These molecules establish a distinct family of sialic acid-dependent adhesion molecules, the sialoadhesin family. We have mapped the rodent sialoadhesin gene, Sn, to chromosome 2F-H1 by in situ hybridization (ISH) and shown linkage to Il1b and four other markers by backcross linkage analysis. We have also used ISH and a human-mouse somatic cell hybrid panel to localize the human sialoadhesin gene, SN, to the conserved syntenic region on human chromosome 20p13. This demonstrates that the sialoadhesin gene is not linked to the other members of the Sialoadhesin family, CD22, MAG, and CD33, which have been independently mapped to the distal region of mouse chromosome 7 and to human chromosome 19q13.1-3.

摘要

唾液酸粘附素是一种由组织巨噬细胞亚群表达的细胞间相互作用分子。它含有17个免疫球蛋白（Ig）样结构域，在结构上与CD22、髓鞘相关糖蛋白（MAG）和CD33相关。这些分子构成了一个独特的唾液酸依赖性粘附分子家族，即唾液酸粘附素家族。我们通过原位杂交（ISH）将啮齿动物唾液酸粘附素基因Sn定位到染色体2F-H1，并通过回交连锁分析显示它与Il1b及其他四个标记物连锁。我们还利用ISH和人-鼠体细胞杂交板将人类唾液酸粘附素基因SN定位到人类染色体20p13上的保守同线区域。这表明唾液酸粘附素基因与唾液酸粘附素家族的其他成员CD22、MAG和CD33没有连锁关系，后者已分别独立定位到小鼠染色体7的远端区域和人类染色体19q13.1-3。