Laboratory for Cancer Immunotherapy, Department of Biomedicine, University, of Basel, Basel, Switzerland.
Division of Oncology, University Hospital Basel, Basel, Switzerland.
Cancer Immunol Res. 2022 Dec 2;10(12):1423-1432. doi: 10.1158/2326-6066.CIR-22-0366.
The sialic acid-binding immunoglobulin-like lectin (Siglec)-sialic acid immune axis is an evolutionarily conserved immunoregulatory pathway that provides a mechanism for establishing self-recognition and combatting invasive pathogens. Perturbations in the pathway lead to many immune dysregulated diseases, including autoimmunity, neurodegeneration, allergic conditions, and cancer. The purpose of this review is to provide a brief overview of the relationship between Siglecs and sialic acid as they relate to human health and disease, to consider current Siglec-based therapeutics, and to discuss new therapeutic approaches targeting the Siglec-sialic acid immune axis, with a focus on cancer.
唾液酸结合免疫球蛋白样凝集素 (Siglec)-唾液酸免疫轴是一种进化上保守的免疫调节途径，为建立自我识别和对抗入侵病原体提供了一种机制。该途径的紊乱会导致许多免疫失调疾病，包括自身免疫、神经退行性疾病、过敏和癌症。本综述的目的是简要概述 Siglecs 与唾液酸之间的关系，以及它们与人类健康和疾病的关系，考虑基于 Siglec 的当前治疗方法，并讨论针对 Siglec-唾液酸免疫轴的新治疗方法，重点是癌症。
