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人类VSNL1基因(大鼠类视锥蛋白样肽RNVP1的同源物)的序列特征与基因定位

Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1.

作者信息

Polymeropoulos M H, Ide S, Soares M B, Lennon G G

机构信息

Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Genomics. 1995 Sep 1;29(1):273-5. doi: 10.1006/geno.1995.1244.

Abstract

In the course of isolation and sequence analysis of microsatellite repeat containing human cDNAs, we have isolated the human homologue of the rat visinin-like peptide gene. The human gene shows a high degree of conservation at both the amino acid and the DNA sequence level. The (CA)n microsatellite repeat embedded in the 3' untranslated region of the gene is conserved between rat and human, along with the flanking DNA sequences. We have mapped the VSNL1 gene to the short arm of chromosome 2.

摘要

在对含微卫星重复序列的人类cDNA进行分离和序列分析的过程中,我们分离出了大鼠类视锥蛋白样肽基因的人类同源物。该人类基因在氨基酸和DNA序列水平上都表现出高度保守性。该基因3'非翻译区中嵌入的(CA)n微卫星重复序列以及侧翼DNA序列在大鼠和人类之间是保守的。我们已将VSNL1基因定位到2号染色体短臂上。

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