Labarre D, Jozefowicz M, Boffa M C
J Biomed Mater Res. 1977 Mar;11(2):283-95. doi: 10.1002/jbm.820110212.
A heparin--poly(methyl methacrylate) copolymer in which heparin has been covalently bound was studied. This copolymer showed no release of heparin but presented heparin-like anticoagulant activity when suspended in plasma. After contact with plasma, the copolymer lost part of its antithrombin activity which could be restored by a high ionic-strength medium. Because of its solid form, this copolymer offers new possibilities for producing interesting anticoagulant surfaces.
对一种肝素已共价结合的肝素 - 聚（甲基丙烯酸甲酯）共聚物进行了研究。这种共聚物未表现出肝素释放，但悬浮于血浆中时呈现出类肝素抗凝活性。与血浆接触后，该共聚物失去了部分抗凝血酶活性，而这种活性可通过高离子强度介质恢复。由于其固体形式，这种共聚物为制造有趣的抗凝表面提供了新的可能性。
