Kronick P L, Rembaum A
J Biomed Mater Res. 1977 Jan;11(1):39-50. doi: 10.1002/jbm.820110106.
We have studied the contact interaction of platelets with hydrogels. In the form of microspheres, 0.6-1.0 mu, poly(glycol methacrylate) (polyHEMA) and poly(methyl methacrylate) beads cause platelets to aggregate at concentrations of about 10(8) beads/ml. Polyacrylamide and (20/80) poly(acrylamide-HEMA) copolymer were ineffective in aggregating platelets. The admixture of 20% methacrylate to polyHEMA rendered the beads inactive. Blood plasma components other than fibrinogen were found essential to the interaction of the beads with platelets. Near-infrared spectra of the hydrogels polyacrylamide and polyHEMA showed the water hydrogen bonds to be the same for both and different from those in pure water. The monomer HEMA is an inhibitor of platelet aggregation and the release reaction at levels of 0.1%. It is concluded that the two hydrogels have different blood compatibilities, which depend more on the network structures than the water structures in the respective gels.
我们研究了血小板与水凝胶的接触相互作用。以微球形式存在的0.6 - 1.0微米的聚（甲基丙烯酸乙二醇酯）（聚甲基丙烯酸羟乙酯，polyHEMA）和聚（甲基丙烯酸甲酯）珠粒在浓度约为10⁸个珠粒/毫升时会导致血小板聚集。聚丙烯酰胺和（20/80）聚（丙烯酰胺 - 甲基丙烯酸羟乙酯）共聚物在使血小板聚集方面无效。向聚甲基丙烯酸羟乙酯中添加20%的甲基丙烯酸会使珠粒失去活性。发现除纤维蛋白原外的血浆成分对于珠粒与血小板的相互作用至关重要。聚丙烯酰胺和聚甲基丙烯酸羟乙酯水凝胶的近红外光谱显示两者的水氢键相同，且与纯水中的不同。单体甲基丙烯酸羟乙酯在0.1%的水平下是血小板聚集和释放反应的抑制剂。得出的结论是，这两种水凝胶具有不同的血液相容性，这更多地取决于各自凝胶中的网络结构而非水结构。
