Calovini T, Haase H, Morano I
Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany.
J Cell Biochem. 1995 Sep;59(1):69-78. doi: 10.1002/jcb.240590109.
We investigated the effects of ovarectomy and the steroid hormones estrogen and testosterone on the in vivo expression of heavy (MHC) and light (MLC) chains of myosin in the heart, uterus, and aorta of rats. In the heart, ovarectomy decreased alpha-MHC expression, while both steroid hormones normalized it. Differential steroid hormone effects could be observed on myosin subunit expression of smooth muscle. Testosterone but not estrogen normalized the ovarectomy-induced decreased expression of SM1 and strongly increased the expression of 5'-inserted MHC in the uterus. Estrogen but not testosterone normalized the ovarectomy-induced diminished MLC17a expression. In contrast to the uterus, no steroid hormone effects on myosin subunit expression could be observed in the aorta.
我们研究了卵巢切除术以及类固醇激素雌激素和睾酮对大鼠心脏、子宫和主动脉中肌球蛋白重链（MHC）和轻链（MLC）体内表达的影响。在心脏中，卵巢切除术降低了α-MHC的表达，而两种类固醇激素使其恢复正常。在平滑肌的肌球蛋白亚基表达上可观察到类固醇激素的不同作用。睾酮而非雌激素使卵巢切除引起的SM1表达降低恢复正常，并强烈增加子宫中5'-插入型MHC的表达。雌激素而非睾酮使卵巢切除引起的MLC17a表达减少恢复正常。与子宫不同，在主动脉中未观察到类固醇激素对肌球蛋白亚基表达的影响。
