Johansen K, Rasmussen M H, Kjems L L, Astrup A
Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark.
J Clin Endocrinol Metab. 1995 Dec;80(12):3442-6. doi: 10.1210/jcem.80.12.8530581.
A mother and her daughter with a novel type of familial partial lipodystrophy were studied. Both had atrophy of fat in the face, chest, and upper and lower limbs and abdominal obesity caused by intraabdominal fat accumulation. The mother had severe insulin resistance and impaired glucose tolerance, whereas the daughter had normal glucose tolerance and normal insulin sensitivity. Both had metabolic rates about 30% above normal levels, but normal thyroid function and plasma lipids.
对一位患有新型家族性部分脂肪营养不良的母亲及其女儿进行了研究。两人均存在面部、胸部、上下肢脂肪萎缩以及由腹内脂肪堆积导致的腹部肥胖。母亲有严重的胰岛素抵抗和糖耐量受损，而女儿的糖耐量正常且胰岛素敏感性正常。两人的代谢率均比正常水平高约30%，但甲状腺功能和血脂正常。
