源自小鼠的已建细胞系产生纤溶酶原激活物。
Production of plasminogen activator by established cell lines of mouse origin.
作者信息
Rifkin D B, Pollack R
出版信息
J Cell Biol. 1977 Apr;73(1):47-55. doi: 10.1083/jcb.73.1.47.
Abstract
The correlation between malignant transformation and increased plasminogen activator synthesis has been studied in a variety of established cell lines. In contrast to the behavior of secondary mouse embryo cultures, which always show increased fibrinolytic activity when transformed, no such correlation was found within the BALB/c 3T3 line and its transformed derivatives. Cell lines were established from tumors initiated in BALB/c mice by several transformed cell lines. These lines were generally found to contain no more plasminogen activator than the cells used for inoculation. A correlation was found between transformation and plasminogen activator synthesis within Swiss 3T3 cell lines. However, the correlation was not maintained by serum revertants of transformed Swiss 3T3 cells.
摘要
在多种已建立的细胞系中，对恶性转化与纤溶酶原激活物合成增加之间的相关性进行了研究。与二次小鼠胚胎培养物的行为相反，二次小鼠胚胎培养物在转化时总是显示出纤溶酶活性增加，但在BALB/c 3T3细胞系及其转化衍生物中未发现这种相关性。从几种转化细胞系在BALB/c小鼠中引发的肿瘤建立了细胞系。这些细胞系通常被发现所含的纤溶酶原激活物并不比用于接种的细胞更多。在瑞士3T3细胞系中发现了转化与纤溶酶原激活物合成之间的相关性。然而，转化的瑞士3T3细胞的血清回复突变体并未保持这种相关性。
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本文引用的文献
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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.对培养的小鼠胚胎细胞生长及其发育成既定细胞系的定量研究。
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Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.转化细胞中蛋白酶水平升高：一种用于检测纤溶酶原激活物产生的酪蛋白覆盖分析方法。
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Lack of correlation between fibrinolysis and the transformed state of cultured mammalian cells.纤溶作用与培养的哺乳动物细胞转化状态之间缺乏相关性。
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