DeRouen T A, Hujoel P P, Mancl L A
Department of Biostatistics, University of Washington, Seattle 98195-7475, USA.
J Dent Res. 1995 Nov;74(11):1731-7. doi: 10.1177/00220345950740110301.
In the past 10 to 12 years, there have been several statistical issues identified in periodontal research which require and have generated non-standard or new statistical approaches. The purpose of this paper is to give an overview of these issues and approaches. Three general categories of issues are described: (i) statistical methods for detecting when disease progression occurs, and biological theories and corresponding statistical models which attempt to describe how the disease progresses; (ii) design issues in studies of therapeutic efficacy; and (iii) analytic issues arising from periodontal data analysis.
在过去的10到12年里，牙周病研究中发现了几个统计学问题，这些问题需要并催生了非标准或新的统计方法。本文旨在对这些问题和方法进行概述。文中描述了三类常见问题：（i）检测疾病进展发生时间的统计方法，以及试图描述疾病进展方式的生物学理论和相应的统计模型；（ii）治疗效果研究中的设计问题；（iii）牙周数据分析中出现的分析问题。
