Gussekloo J, Heeren T J, Izaks G J, Ligthart G J, Rooijmans H G
Department of Psychiatry, Leiden University, The Netherlands.
J Neurol Neurosurg Psychiatry. 1995 Nov;59(5):507-10. doi: 10.1136/jnnp.59.5.507.
The aim was to investigate the incidence rate of dementia for community residents aged 85 years and over. It was a two wave community study of 224 subjects (community residents including those residing in a nursing home) older than 85 years, restudied 4.1 years after a community prevalence study. A two stage method was used, comprising the mini mental state examination followed in a stratified sample by the geriatric mental state schedule (A3)/AGECAT. Incidence rates were based on person-years at risk. The overall incidence of dementia was 6.9 (95% confidence interval (95% CI) 4.8-9.1) per 100 person-years at risk. The incidence was significantly higher for women than for men; respectively 8.9 (95% CI 5.9-11.9) v 2.7 (95% CI 0.5-4.9) per 100 person-years at risk. In the fastest growing age group seven out of 100 persons develop dementia each year. Women, who constitute two thirds of the oldest old, seem to have a higher risk. Further research is needed into the risk factors for dementia in this age group.
研究目的是调查85岁及以上社区居民的痴呆发病率。这是一项针对224名85岁以上受试者(包括住在养老院的社区居民)的两阶段社区研究,在一项社区患病率研究4.1年后进行重新研究。采用两阶段方法,首先进行简易精神状态检查,然后在分层样本中采用老年精神状态量表(A3)/AGECAT。发病率基于风险人年数。痴呆的总体发病率为每100风险人年6.9例(95%置信区间(95%CI)4.8 - 9.1)。女性的发病率显著高于男性;每100风险人年分别为8.9例(95%CI 5.9 - 11.9)和2.7例(95%CI 0.5 - 4.9)。在增长最快的年龄组中,每年每100人中有7人患痴呆。占最年长者三分之二的女性似乎风险更高。需要进一步研究该年龄组痴呆的风险因素。