Heeren T J, Lagaay A M, Hijmans W, Rooymans H G
Department of Psychiatry Leiden University, The Netherlands.
J Am Geriatr Soc. 1991 Aug;39(8):755-9. doi: 10.1111/j.1532-5415.1991.tb02696.x.
To estimate the prevalence rate of dementia in subjects 85 years of age and over.
A two-phase design with the Mini-Mental State Examination (MMSE) in the screening phase and the Geriatric Mental State Schedule (GMS) in the diagnostic phase.
Community survey including subjects in residential care.
All (n = 1,259) inhabitants of Leiden, The Netherlands, aged 85 years and over on December 1, 1986. First phase participation rate was 71% (17% dropout due to death); second phase participation rate was 82%.
DSM-III diagnosis of dementia without further specification of the etiology of the dementia.
An overall prevalence rate of 23% (95% C.I.: 19%-26%) was found. This included 12% mild dementia, 7% moderate and 4% severe dementia. The prevalence rate was higher among women (24%) than among men (18%). It increased with age from 19% (95% C.I.: 16%-22%) in the group of 85-89 years to 32% (95% C.I.: 26%-39%) in the group of 90-94 years to 41% (95% C.I.: 25%-58%) in the 95+ group.
A fifth of the 85+ and a third of the 90+ population suffer from dementia with an indication that half of the 95+ population is affected. With the expected steep rise in the number of the oldest old, dementia will stay a major health problem in the near future.
评估85岁及以上人群中痴呆症的患病率。
采用两阶段设计,筛查阶段使用简易精神状态检查表(MMSE),诊断阶段使用老年精神状态检查表(GMS)。
社区调查,包括接受机构照料的人群。
1986年12月1日时,荷兰莱顿所有年龄在85岁及以上的居民(n = 1259)。第一阶段参与率为71%(17%因死亡退出);第二阶段参与率为82%。
未进一步明确痴呆病因的《精神疾病诊断与统计手册》第三版(DSM-III)痴呆症诊断。
总体患病率为23%(95%置信区间:19% - 26%)。其中轻度痴呆占12%,中度痴呆占7%,重度痴呆占4%。女性患病率(24%)高于男性(18%)。患病率随年龄增长而升高,85 - 89岁组为19%(95%置信区间:16% - 22%),90 - 94岁组为32%(95%置信区间:26% - 39%),95岁及以上组为41%(95%置信区间:25% - 58%)。
85岁及以上人群中有五分之一、90岁及以上人群中有三分之一患有痴呆症,且有迹象表明95岁及以上人群中有一半受到影响。随着高龄老人数量预计的急剧增加,痴呆症在不久的将来仍将是一个主要的健康问题。