Zimmerman T S, de la Pointe L, Edgington T S
J Clin Invest. 1977 May;59(5):984-9. doi: 10.1172/JCI108721.
By utilizing a simple modification of previous immunological assays, we have demonstrated that most, if not all, hemophilic plasmas contain antigen reactive with human antibodies directed against Factor VIII procoagulant activity (VIIIc). Antibodies developing in a nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von Willebrand's disease antigen. These data suggest that there are greater antigenic similarities between normal and hemophilic Factor VIII than previously thought.
通过对先前免疫测定法进行简单修改，我们已证明，大多数（即便不是全部）血友病血浆含有与针对凝血因子VIII促凝血活性（VIIIc）的人抗体发生反应的抗原。在一名非血友病患者和一名血友病患者体内产生的抗体给出了相似的结果。如此鉴定出的VIIIc抗原可通过与正常VIIIc和血管性血友病抗原发生反应的固定化兔抗体从血友病血浆中去除。这些数据表明，正常和血友病的凝血因子VIII之间的抗原相似性比之前认为的更高。
