Masaki N, Hayashi S
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Nihon Rinsho. 1995 Oct;53(10):2530-5.
Sjögren's syndrome (SjS) has been well known to complicate autoimmune liver diseases such as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). In addition, it has been recently described that chronic viral hepatitis type C could be accompanied by a sialadenitis resembling SjS. Among 98 patients with SjS at our clinic, 7 AIH, 1 PBC, and at least 11 hepatitis C virus (HCV) infection were noted. However, occurrence of SjS was not always associated with the severity of chronic liver diseases. Our present study suggested that three mechanisms might contribute to the pathogenesis of HCV-related SjS: 1) direct infection and proliferation of HCV in salivary glands, 2) molecular mimicry between HCV and salivary glands, and 3) formation of immune complex containing HCV. Further investigation would be indispensable to elucidate immunological systems to regulate these phenomena.
干燥综合征（SjS）常并发自身免疫性肝病，如自身免疫性肝炎（AIH）和原发性胆汁性肝硬化（PBC），这已广为人知。此外，最近有报道称，丙型慢性病毒性肝炎可能伴有类似干燥综合征的涎腺炎。在我们诊所的98例干燥综合征患者中，发现7例自身免疫性肝炎、1例原发性胆汁性肝硬化和至少11例丙型肝炎病毒（HCV）感染。然而，干燥综合征的发生并不总是与慢性肝病的严重程度相关。我们目前的研究表明，三种机制可能与丙型肝炎病毒相关干燥综合征的发病机制有关：1）丙型肝炎病毒在涎腺中的直接感染和增殖；2）丙型肝炎病毒与涎腺之间的分子模拟；3）含丙型肝炎病毒免疫复合物的形成。进一步的研究对于阐明调节这些现象的免疫系统必不可少。
