Nishiyama S, Miyawaki S, Hashimoto T
Center for Adult Diseases Kurashiki, Minami Kurashiki Hospital.
Nihon Rinsho. 1995 Oct;53(10):2551-6.
Cutaneous manifestations including purpura, annular erythema and pernio-like erythema are one of the extraglandular findings of primary Sjögren's syndrome (SS). Histopathologically, inflammatory vascular lesions are frequently detected. Two types of annular erythema, edematous and atrophic types, can be seen. Histopathologically, atrophic annular erythema is hardly distinguished from SCLE. Skin lesions of primary SS, especially purpura and edematous annular erythema, are related with anti-SS-A/Ro and SS-B/La antibodies. Some of the cutaneous manifestations develop both in primary SS and lupus erythematosus and anti-SS-A/Ro and SS-B/La antibodies may play an important role in the development of these cutaneous lesions.
皮肤表现包括紫癜、环形红斑和冻疮样红斑是原发性干燥综合征（SS）的腺外表现之一。组织病理学上，常检测到炎症性血管病变。可见两种类型的环形红斑，即水肿型和萎缩型。组织病理学上，萎缩性环形红斑很难与亚急性皮肤型红斑狼疮区分开来。原发性SS的皮肤病变，尤其是紫癜和水肿性环形红斑，与抗SS-A/Ro和SS-B/La抗体有关。一些皮肤表现既见于原发性SS，也见于红斑狼疮，抗SS-A/Ro和SS-B/La抗体可能在这些皮肤病变的发生中起重要作用。
