McCauliffe D P, Faircloth E, Wang L, Hashimoto T, Hoshino Y, Nishikawa T
Department of Dermatology, University of North Carolina, Chapel Hill, USA.
Arch Dermatol. 1996 May;132(5):528-31.
Studies were conducted to determine whether certain types of Ro autoantibodies are unique to subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome. Ten American subacute cutaneous lupus erythematosus sera, 11 Japanese annular erythema of Sjögren's syndrome sera, and 39 control sera were tested by enzyme-linked immunosorbent assay with recombinant 52- and 60-kd Ro fusion proteins, native 60-kd Ro protein, and native La/SS-B protein.
Japanese annular erythema of Sjögren's syndrome sera and American subacute cutaneous lupus erythematosus sera share several types of anti-52-kd and anti-60-kd Ro autoantibodies. However, these antibodies were found significantly more often and in significantly higher titers in sera from patients with Sjögren's syndrome who did not manifest these skin diseases. Patients with high Ro autoantibody titers were likely to have overt exocrine gland dysfunction.
The failure to identify disease-specific Ro autoantibodies in subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome sera suggests that additional factors influence the development of these skin diseases. However, similarities in the Ro autoantibody responses and in the clinical features of subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome suggest that these two skin diseases might arise from a similar pathogenic process.
开展研究以确定某些类型的Ro自身抗体是否为亚急性皮肤型红斑狼疮和干燥综合征环形红斑所特有。采用重组52-kd和60-kd Ro融合蛋白、天然60-kd Ro蛋白以及天然La/SS - B蛋白，通过酶联免疫吸附测定法对10份美国亚急性皮肤型红斑狼疮血清、11份日本干燥综合征环形红斑血清以及39份对照血清进行检测。
日本干燥综合征环形红斑血清和美国亚急性皮肤型红斑狼疮血清具有几种类型的抗52-kd和抗60-kd Ro自身抗体。然而，在未出现这些皮肤疾病的干燥综合征患者血清中，这些抗体的出现频率显著更高且滴度显著更高。Ro自身抗体滴度高的患者可能存在明显的外分泌腺功能障碍。
在亚急性皮肤型红斑狼疮和干燥综合征环形红斑血清中未能鉴定出疾病特异性的Ro自身抗体，这表明还有其他因素影响这些皮肤疾病的发生。然而，亚急性皮肤型红斑狼疮和干燥综合征环形红斑在Ro自身抗体反应及临床特征方面的相似性表明，这两种皮肤疾病可能源于相似的致病过程。
