Tendler M, Vilar M M, Brito C A, Freire N M, Katz N, Simpson A
Departamento de Helmintologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz. 1995 Mar-Apr;90(2):255-6. doi: 10.1590/s0074-02761995000200022.
Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.
保护性抗原制剂成分的分子克隆表明，相关的寄生虫脂肪酸结合蛋白可能是肝片吸虫和曼氏血吸虫这两种寄生吸虫之间有充分文献记载的保护性免疫交叉反应的基础。我们现已证实了寄生虫脂肪酸结合蛋白的交叉保护潜力，并提出有可能生产出一种对至少两种分别对兽医和人类具有重要意义的寄生虫（肝片吸虫和曼氏血吸虫）有效的单一疫苗。
