Giles W B, McLean M, Davies J J, Smith R
Maternal Health Research Centre, John Hunter Hospital, Newcastle, Australia.
Obstet Gynecol. 1996 Jan;87(1):107-11. doi: 10.1016/0029-7844(95)00338-x.
To determine whether placental secretion of corticotropin-releasing hormone into the fetal circulation is increased in pregnancies complicated by umbilical-placental vascular insufficiency.
Twenty women with abnormal Doppler umbilical artery flow velocity waveforms and six women with uncomplicated term pregnancies and normal umbilical artery flow velocity waveforms had cord blood concentrations of corticotropin-releasing hormone, ACTH, cortisol, and beta-hCG estimated.
The mean cord blood corticotropin-releasing hormone concentration was significantly higher in pregnancies with abnormal umbilical artery flow velocity waveforms than in normal pregnancies (108 +/- 27 versus 24 +/- 8 pg/mL, P = .019). Elevated cord blood corticotropin-releasing hormone levels were seen in the abnormal group regardless of the presence or absence of preeclampsia or fetal growth restriction. There were no significant differences in cord blood cortisol, ACTH, or beta-hCG concentrations.
The concentration of corticotropin-releasing hormone in the fetal circulation is significantly increased in pregnancies complicated by abnormal umbilical artery flow velocity waveforms. This may represent a stress-responsive compensatory mechanism in the human placenta.
确定在合并脐-胎盘血管功能不全的妊娠中，胎盘向胎儿循环分泌促肾上腺皮质激素释放激素是否增加。
对20例脐动脉血流速度波形异常的孕妇和6例足月妊娠且脐动脉血流速度波形正常的未合并症孕妇的脐血中促肾上腺皮质激素释放激素、促肾上腺皮质激素、皮质醇和β-人绒毛膜促性腺激素浓度进行了测定。
脐动脉血流速度波形异常的妊娠中，脐血促肾上腺皮质激素释放激素的平均浓度显著高于正常妊娠（108±27对24±8 pg/mL，P = 0.019）。无论是否存在子痫前期或胎儿生长受限，异常组中均可见脐血促肾上腺皮质激素释放激素水平升高。脐血皮质醇、促肾上腺皮质激素或β-人绒毛膜促性腺激素浓度无显著差异。
合并脐动脉血流速度波形异常的妊娠中，胎儿循环中促肾上腺皮质激素释放激素的浓度显著增加。这可能代表了人胎盘中一种应激反应性代偿机制。
