Bovo G, Brivio F, Brenna A, Fumagalli L, Perego P, Brivio O, Uggeri F, Lavorato F, Bratina G
Servizio di Anatomia Patologia, Ospedale di Monza.
Pathologica. 1995 Apr;87(2):135-8.
Interleukin-2 (IL-2) may induce peripheral eosinophilia and this phenomenon is related with response to IL-2 immunotherapy in patients with metastatic renal cell carcinoma. In previous experiences is reported that preoperative course with IL-2 may reverse the surgery-induced immunosuppression. This study's objective is to evaluate the histological changes of inflammatory infiltration in tumour stroma, in patients pretreated with IL-2 immunotherapy. 7 patients admitted to our surgical department with resectable recurrent colorectal cancer were treated with pre-operative course of IL-2; the tissue samples were analyzed for eosinophilic and inflammatory infiltration and compared with the samples obtained in the primary operation, performed without immunotherapy. In all patients were observed an increase of eosinophilic infiltration in tumour tissue. The mean increase were 200%, with high statistical significance (p < 0.0001). IL-2 pre-operative immunotherapy is able to change the interaction between host and tumour, by modifying the histological inflammatory infiltration in colorectal cancer tissue.
白细胞介素-2（IL-2）可能会诱导外周血嗜酸性粒细胞增多，这种现象与转移性肾细胞癌患者对IL-2免疫治疗的反应有关。在以往的经验中，有报道称术前使用IL-2疗程可能会逆转手术引起的免疫抑制。本研究的目的是评估接受IL-2免疫治疗预处理的患者肿瘤基质中炎症浸润的组织学变化。7例入住我院外科的可切除复发性结直肠癌患者接受了术前IL-2疗程治疗；对组织样本进行嗜酸性粒细胞和炎症浸润分析，并与在未进行免疫治疗的初次手术中获得的样本进行比较。在所有患者中均观察到肿瘤组织中嗜酸性粒细胞浸润增加。平均增加了200%，具有高度统计学意义（p < 0.0001）。术前IL-2免疫治疗能够通过改变结直肠癌组织中的组织学炎症浸润来改变宿主与肿瘤之间的相互作用。
