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单次剂量放疗(6 Gy):用于缓解骨转移疼痛。

Single-dose radiotherapy (6 Gy): palliation in painful bone metastases.

作者信息

Uppelschoten J M, Wanders S L, de Jong J M

机构信息

Institute for Radiotherapy, R.T.I.L., Heerlen, The Netherlands.

出版信息

Radiother Oncol. 1995 Sep;36(3):198-202. doi: 10.1016/0167-8140(95)01587-7.

Abstract

Approximately 50% of patients with cancer develop bone metastases and these have an important influence on the quality of life. PURPOSE OF THE STUDY. To evaluate a lower dose than the one already proven to be effective (8 Gy) in the palliation of painful bone metastases. METHODS AND MATERIALS. In a prospective study we analyzed the pain relief, after a single dose of 6 Gy, in 170 patients with painful bone metastases. This was assessed by a questionnaire. RESULTS. A degree of pain relief, was achieved in 88% of the treatments and there was complete relief in 39%. When the treatment was given to the vertebrae, infield spinal cord compression developed in 9%, and when given to the pelvis or femur, infield fractures developed in 8%. CONCLUSION. We concluded that a single dose of 6 Gy was very effective in the palliation of painful bone metastases.

摘要

约50%的癌症患者会发生骨转移,这些骨转移对生活质量有重要影响。研究目的。评估一种比已被证明在缓解骨转移疼痛方面有效的剂量(8 Gy)更低的剂量。方法和材料。在一项前瞻性研究中,我们分析了170例骨转移疼痛患者单次给予6 Gy剂量后的疼痛缓解情况。这通过问卷调查进行评估。结果。88%的治疗实现了一定程度的疼痛缓解,39%实现了完全缓解。当对椎体进行治疗时,9%发生了野内脊髓压迫,当对骨盆或股骨进行治疗时,8%发生了野内骨折。结论。我们得出结论,单次给予6 Gy对缓解骨转移疼痛非常有效。

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