错配修复：机制及其与癌症易感性的关系。
Mismatch repair: mechanisms and relationship to cancer susceptibility.
作者信息
Kolodner R D
机构信息
Division of Human Cancer Genetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
Trends Biochem Sci. 1995 Oct;20(10):397-401. doi: 10.1016/s0968-0004(00)89087-8.
PMID:8533151
Abstract
DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.
摘要
存在DNA错配修复系统，可修复在DNA复制、基因重组过程中以及DNA损伤后形成的错配碱基。这些系统的一些组成部分在原核生物和真核生物中是保守的。错配修复基因中的遗传缺陷在常见的癌症易感性综合征和散发性癌症中起重要作用。
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