Integrated Anatomic Pathology Center Oswaldo Cruz University Hospital University of Pernambuco (UPE) R. Arnóbio Marques, 310 Santo Amaro Recife - PE, 50100-130, Brazil
Med Oral Patol Oral Cir Bucal. 2024 Sep 1;29(5):e655-e664. doi: 10.4317/medoral.26647.
The DNA mismatch repair (MMR) system serves as a sophisticated guardian of the precise functioning of the human genome. Dysregulation within this system is linked to the oncogenesis process. Reduced expression of MMR system proteins identified in salivary gland tumors (SGTs) suggests an increased risk of tumoral occurrence. This study aims to analyze the expression of MMR proteins in SGTs and discuss the relevance of this association to the development of these neoplasms.
This review was conducted following the PRISMA guidelines and was registered in PROSPERO (CRD42023465590). A comprehensive search of the PubMed/MEDLINE, Web of Science, Scopus, Embase, and ProQuest (non-peer reviewed platform) was performed to answer the question "Do DNA MMR system proteins exhibit expression in SGTs?". The methodological quality of the selected studies was assessed using the JBI's Critical Appraisal Tool.
A total of 142 patients with benign SGTs and 84 with malignant SGTs were included in this review. The literature analysis showed a notable reduction in the expression of DNA MMR system proteins (hHMS2, hMLH1, hMSH3 and hMSH6) in the percentage of marked cells.
The reduction in the expression of the DNA MMR system proteins suggests an interesting correlation with the development of malignant and benign SGTs. Nevertheless, further investigations are warranted to better clarify the precision of measuring biomarker protein expression.
DNA 错配修复（MMR）系统是人类基因组精确功能的精密守护者。该系统的失调与肿瘤发生过程有关。唾液腺肿瘤（SGT）中发现的 MMR 系统蛋白表达减少表明肿瘤发生的风险增加。本研究旨在分析 SGT 中 MMR 蛋白的表达，并讨论这种关联与这些肿瘤发生的相关性。
本综述遵循 PRISMA 指南进行，并在 PROSPERO（CRD42023465590）中进行了注册。对 PubMed/MEDLINE、Web of Science、Scopus、Embase 和 ProQuest（非同行评审平台）进行了全面检索，以回答“DNA MMR 系统蛋白在 SGT 中是否有表达？”这一问题。使用 JBI 的Critical Appraisal Tool 评估了所选研究的方法学质量。
本综述共纳入 142 例良性 SGT 患者和 84 例恶性 SGT 患者。文献分析显示，在标记细胞百分比中，DNA MMR 系统蛋白（hHMS2、hMLH1、hMSH3 和 hMSH6）的表达显著降低。
DNA MMR 系统蛋白表达的降低表明与恶性和良性 SGT 的发展具有有趣的相关性。然而，需要进一步的研究来更好地阐明测量生物标志物蛋白表达的准确性。
