Heatley M K
Department of Pathology, University of Sheffield Medical School.
Ulster Med J. 1995 Oct;64(2):147-50.
The value of dipping cervical cone biopsy specimens in iodine (the Schiller test) as a method of deciding which areas should be selected for histological examination was assessed. Schiller positive and negative areas were recorded in macroscopic specimen images from fifty specimens of cervix. The results were compared with the histological presence or absence of cervical intraepithelial neoplasia (CIN) or invasive malignancy. In 84% of cases the test was a reliable means of predicting the presence or absence of squamous CIN; in two cases it was positive in association with endocervical adenocarcinoma in situ. A false positive and false negative Schiller's test was present in three cases (6%) each. Had this method been adopted as the sole means of selecting blocks for histological examination the areas of CIN would have been missed in 6% of cases. Therefore it is not a sound alternative to the submission of all tissue for histological examination.
评估了将宫颈锥形活检标本浸入碘液中（席勒试验）作为决定应选择哪些区域进行组织学检查的方法的价值。在五十份宫颈标本的宏观标本图像中记录席勒试验阳性和阴性区域。将结果与宫颈上皮内瘤变（CIN）或浸润性恶性肿瘤的组织学存在与否进行比较。在84%的病例中，该试验是预测鳞状CIN存在与否的可靠方法；在两例病例中，该试验呈阳性，与宫颈原位腺癌相关。席勒试验分别在三例病例（6%）中出现假阳性和假阴性。如果将此方法作为选择组织学检查切片的唯一方法，6%的病例中将会遗漏CIN区域。因此，它并非提交所有组织进行组织学检查的可靠替代方法。
