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[光照增强对抑郁症患者褪黑素排泄的影响]

[Melatonin excretion in patients with depression under the action of light of increased intensity].

作者信息

Bozhko G Kh, Tsaritsinskiĭ V I, Kulabukhov V M, Taranskaia A D

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1995;95(4):51-3.

PMID:8533510
Abstract

The effects of 1 and 10 bright light exposures (2600-8000 lux) on melatonin excretion in patients with melancholic and anxious depressions were examined. Before treatment the increased basic levels of melatonin excretion were observed in patients with anxious depression. Melatonin excretion had been gradually normalized after 1 and 10 sessions of light therapy. The basic melatonin excretion in melancholic depressed patients was low and hadn't been changed after light therapy. Long term effects of light therapy depend upon the initial levels of melatonin excretion: low pretreatment levels increased and high pretreatment levels decreased after the therapy. The authors proposed that bright light exposures stimulated the restoration of adaptive function of pineal gland in depressed patients.

摘要

研究了1次和10次强光照射(2600 - 8000勒克斯)对抑郁性抑郁症和焦虑性抑郁症患者褪黑素排泄的影响。治疗前,观察到焦虑性抑郁症患者的褪黑素排泄基础水平升高。经过1次和10次光疗后,褪黑素排泄逐渐恢复正常。抑郁性抑郁症患者的褪黑素排泄基础水平较低,光疗后未发生变化。光疗的长期效果取决于褪黑素排泄的初始水平:治疗前水平低的患者治疗后升高,治疗前水平高的患者治疗后降低。作者提出,强光照射刺激了抑郁症患者松果体适应性功能的恢复。

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