Mullick B C, Kessel E, Mumford S D
Indian Rural Medical Association, Calcutta, India.
Adv Contracept. 1995 Sep;11(3):239-44. doi: 10.1007/BF01978425.
Two preliminary single-insertion clinical trials of the quinacrine pellet method of non-surgical female sterilization were compared. Both trials used transcervical application of quinacrine, 252 mg, and diclofenac, 75 mg, as pellets. In the first trial (21 April 1992 to 17 February 1993), 58 women received oral contraceptives for three months. In the second trial (19 February 1993 to 25 May 1994), 229 women received medroxyprogesterone acetate, 150 mg IM, at the time of quinacrine insertion. At 18 months, the life-table pregnancy failure rate per 100 women of the first trial was 8.6 (SE 3.7), whereas the failure rate for the medroxyprogesterone acetate group was 0.5 (SE 0.5), p<0.05. There were no serious complications or side-effects in either group. Larger confirming trials with random allocation and long-term systematic follow-up are needed to determine whether a single injection of medroxyprogesterone improves the efficacy of quinacrine.
对非手术女性绝育的喹吖因药丸法的两项初步单插入临床试验进行了比较。两项试验均采用经宫颈施用252毫克喹吖因和75毫克双氯芬酸制成的药丸。在第一项试验（1992年4月21日至1993年2月17日）中，58名女性服用口服避孕药三个月。在第二项试验（1993年2月19日至1994年5月25日）中，229名女性在插入喹吖因时接受了150毫克醋酸甲羟孕酮的肌肉注射。18个月时，第一项试验中每100名女性的生命表妊娠失败率为8.6（标准误3.7），而醋酸甲羟孕酮组的失败率为0.5（标准误0.5），p<0.05。两组均未出现严重并发症或副作用。需要进行更大规模的随机分配和长期系统随访的验证试验，以确定单次注射醋酸甲羟孕酮是否能提高喹吖因的疗效。
