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压片的物理过程。

Physical processes of tableting.

作者信息

Hiestand E N, Wells J E, Peot C B, Ochs J F

出版信息

J Pharm Sci. 1977 Apr;66(4):510-9. doi: 10.1002/jps.2600660413.

DOI:10.1002/jps.2600660413
PMID:853366
Abstract

Shear deformation was shown to occur during the decompression of large compacts made by nonisostatic compression. Some materials undergo fracture when these shear stresses are developed. Other materials withstand these stresses but fracture upon ejection when the stress concentrations at the edge of the die are large. Failure to fracture seems to be related to the ability to relieve stresses by plastic deformation. A test was devised to measure this property, called the brittle fracture propensity.

摘要

在非等静压压缩制成的大型压坯减压过程中会出现剪切变形。当这些剪应力产生时,一些材料会发生断裂。其他材料能够承受这些应力,但当模具边缘的应力集中较大时,在脱模时会发生断裂。未能发生断裂似乎与通过塑性变形释放应力的能力有关。设计了一种测试来测量这种性能,称为脆性断裂倾向。

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