5,6-苯并-2-氮杂双环[2.2.2]辛烷衍生物作为潜在苯吗喃类镇痛药的合成。
Synthesis of 5,6-benzo-2-azabicyclo[2.2.2]octane derivatives as potential benzomorphan-type analgesic agents.
作者信息
Borne R F, Law S J, Wirth P W, Murphy J C
出版信息
J Pharm Sci. 1977 Apr;66(4):594-6. doi: 10.1002/jps.2600660438.
PMID:853374
Abstract
The synthesis of two N-substituted 5,6-benzo-2-azabicyclo[2.2.2]octane analogs of benzomorphan-type analgesics via benzyne addition to appropriate N-substituted N-alkyl-2-pyridones is described. Neither derivative possessed observable analgesic activity at the doses tested.
摘要
描述了通过苯炔加成到适当的N-取代N-烷基-2-吡啶酮来合成两种苯并吗啡烷型镇痛药的N-取代5,6-苯并-2-氮杂双环[2.2.2]辛烷类似物。在所测试的剂量下，两种衍生物均未表现出可观察到的镇痛活性。
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