Ocelli E, Fontanella L, Diena A
Farmaco Sci. 1978 Jun;33(6):401-20.
The synthesis of two new series of 3,8-diazabicyclo [3.2.1] octane derivatives is described. The first series includes some 3-(or 8)-allyl and 3-(or 8)-(3,3-dimethylallyl) derivatives of 3,8-diazabicyclo [3.2.1] octane and 3,8-diazabicyclo [3.2.1] octane-2-one. The second series includes some esters and carbamates of 3-(3-hydroxy-3-methyl)butyl-3,8-diazabicyclo [3.2.1] octane. Two new 3,8-diazabicyclo [3.2.1] octane derivatives structurally related to propoxyphene are also described. Some pharmacological data of these compounds are reported.
本文描述了两个新系列的3,8-二氮杂双环[3.2.1]辛烷衍生物的合成。第一个系列包括3,8-二氮杂双环[3.2.1]辛烷和3,8-二氮杂双环[3.2.1]辛烷-2-酮的一些3-（或8）-烯丙基和3-（或8）-（3,3-二甲基烯丙基）衍生物。第二个系列包括3-（3-羟基-3-甲基）丁基-3,8-二氮杂双环[3.2.1]辛烷的一些酯和氨基甲酸酯。还描述了两种与丙氧芬结构相关的新的3,8-二氮杂双环[3.2.1]辛烷衍生物。报道了这些化合物的一些药理数据。
