Micromethod for determination of meperidine in plasma.
作者信息
Evans M A, Harbison R D
出版信息
J Pharm Sci. 1977 Apr;66(4):599-600. doi: 10.1002/jps.2600660440.
PMID:853375
Abstract
A GLC method utilizing a flame-ionization detector is described for the analysis of meperidine in blood plasma. Meperidine is extracted with ether from plasma that has been made basic with sodium hydroxide. The ether extract is evaporated to dryness, and the residue is dissolved in carbon disulfide for GLC analysis. An internal standard, N',N'-diethylaminoacetyl-2,6-xylidine, is used to quantitate meperidine. The extraction efficiency from plasma is 85%, and as little as 0.05 microng of meperidine can be quantitatively determined in 1 ml of plasma.
摘要
相似文献
1
Micromethod for determination of meperidine in plasma.
J Pharm Sci. 1977 Apr;66(4):599-600. doi: 10.1002/jps.2600660440.
2
GLC microanalyses of phenacetin and acetaminophen plasma levels.非那西丁和对乙酰氨基酚血浆水平的气相色谱微分析。
J Pharm Sci. 1977 Nov;66(11):1628-9. doi: 10.1002/jps.2600661133.
3
GLC determination of meperidine in blood plasma.
J Pharm Sci. 1973 Jun;62(6):907-9. doi: 10.1002/jps.2600620608.
4
Simultaneous determination of meperidine and normeperidine in biofluids.
J Chromatogr. 1976 Oct;125(3):503-10. doi: 10.1016/s0021-9673(00)85713-1.
5
TLC identification adn GLC determination of meperidine and its metabolites in biological fluids.生物流体中哌替啶及其代谢物的薄层色谱鉴别和气相色谱测定
J Pharm Sci. 1981 May;70(5):482-6. doi: 10.1002/jps.2600700504.
6
Gas chromatographic analysis of meperidine and normeperidine: determination in blood after a single dose of meperidine.
J Pharm Sci. 1982 Feb;71(2):166-8. doi: 10.1002/jps.2600710207.
7
GLC microdetermination of indomethacin in plasma.血浆中吲哚美辛的葡萄糖氧化酶微量测定法
J Pharm Sci. 1980 Feb;69(2):219-20. doi: 10.1002/jps.2600690231.
8
GLC determination of plasma acenocoumarol levels.血浆醋硝香豆素水平的葡萄糖氧化酶法测定
J Pharm Sci. 1977 Jun;66(6):799-802. doi: 10.1002/jps.2600660614.
9
Determination of pethidine in plasma by electron capture gas chromatography after reaction with trichloroethyl chloroformate.在与氯甲酸三氯乙酯反应后，通过电子捕获气相色谱法测定血浆中的哌替啶。
J Chromatogr. 1976 Jun 23;121(2):235-42. doi: 10.1016/s0021-9673(00)85019-0.
10
Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.采用带选择性氮检测的气相色谱法同时测定哌替啶（度冷丁）、苯哌替啶及其共同代谢物去甲哌替啶（去甲度冷丁）。
Forensic Sci Int. 1989 Dec;43(3):267-73. doi: 10.1016/0379-0738(89)90154-0.
引用本文的文献
1
Clinical pharmacokinetics of pethidine.哌替啶的临床药代动力学。
Clin Pharmacokinet. 1978 Sep-Oct;3(5):352-68. doi: 10.2165/00003088-197803050-00002.
Zotero 插件