孕晚期三倍体胎儿中额外单倍体染色体组的母源起源。
Maternal origin of extra haploid set of chromosomes in third trimester triploid fetuses.
作者信息
Dietzsch E, Ramsay M, Christianson A L, Henderson B D, de Ravel T J
机构信息
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
出版信息
Am J Med Genet. 1995 Sep 25;58(4):360-4. doi: 10.1002/ajmg.1320580412.
Twenty-six highly polymorphic markers were used to determine the origin of the extra haploid chromosome set in 6 triploid fetuses of type II phenotype. All had reached the third trimester of pregnancy. The extra set was maternal in origin in all cases, supporting previous research indicating longer in utero survival of maternally-derived triploid fetuses. These findings provide evidence for an instance of genomic imprinting in humans.
使用26个高度多态性标记来确定6例II型表型三倍体胎儿中额外单倍体染色体组的来源。所有胎儿均已进入妊娠晚期。在所有病例中，额外的染色体组均来源于母体，这支持了先前的研究，即母体来源的三倍体胎儿在子宫内的存活时间更长。这些发现为人类基因组印记的一个实例提供了证据。
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