Wiedow O, Wiese F, Christophers E
Department of Dermatology, University of Kiel, Germany.
Arch Dermatol Res. 1995;287(7):632-5. doi: 10.1007/BF00371734.
Human leukocyte elastase, a neutrophil-derived serine protease, is present in psoriatic lesions in an enzymatically active form. Our purpose was to assess the significance of human leukocyte elastase determinations in estimating the inflammatory activity of psoriatic lesions. A standardized method was used to analyse lesional elastase activity. Elastase activities were correlated with erythema, induration and hyperkeratosis of psoriatic lesions in 54 patients. Lesional elastase activities were also determined during treatment with salt-water bathing and UVB irradiation. Lesional elastase activity correlated with skin induration and was inversely correlated with hyperkeratosis of the lesions. Psoriatic lesions with high elastase activity responded well to therapy, whereas lesions with low elastase activity appeared to be comparatively resistant. This study shows that by quantitative determination lesional elastase activities it is possible to distinguish predominantly inflammatory from predominantly hyperproliferative psoriasis. The latter shows delayed responsiveness to topical therapy with salt-water bathing plus UVB irradiation.
人白细胞弹性蛋白酶是一种源自中性粒细胞的丝氨酸蛋白酶，以酶活性形式存在于银屑病皮损中。我们的目的是评估测定人白细胞弹性蛋白酶在评估银屑病皮损炎症活性中的意义。采用标准化方法分析皮损弹性蛋白酶活性。对54例患者的皮损弹性蛋白酶活性与银屑病皮损的红斑、硬结和角化过度进行相关性分析。在盐水浴和紫外线B照射治疗期间也测定了皮损弹性蛋白酶活性。皮损弹性蛋白酶活性与皮肤硬结相关，与皮损角化过度呈负相关。弹性蛋白酶活性高的银屑病皮损对治疗反应良好，而弹性蛋白酶活性低的皮损似乎相对耐药。本研究表明，通过定量测定皮损弹性蛋白酶活性，可以区分以炎症为主型和以增殖为主型银屑病。后者对盐水浴加紫外线B照射的局部治疗反应延迟。
