O'Donnell B, Wuebbolt G, Collin R
Moorfields Eye Hospital, London.
Aust N Z J Ophthalmol. 1995 Aug;23(3):207-12. doi: 10.1111/j.1442-9071.1995.tb00158.x.
Amyloid of the eyelid conjunctiva is an extremely rare condition which may result in chronic discomfort and multiple surgeries.
A retrospective study of four patients from Moorfields Eye Hospital is presented to assess the clinical features and results of surgical treatment.
Three patients had persistent ocular irritation and required multiple surgical procedures for recurrent amyloid. However, one patient has been followed for nearly 30 years with relatively few symptoms, and has required only infrequent surgical intervention. All patients underwent debulking and ptosis surgery at least once. The more severe clinical course was not related to the type of amyloid protein present. Shave excision of recurrent tarsal conjunctival amyloid with split-thickness mucous membrane grafting was successfully tried in one patient in order to minimise postoperative cicatrisation of the posterior lamella.
The clinical course of patients with eyelid amyloid may vary greatly. Management should be conservative when possible, but surgery is an integral part of management since debulking of amyloid deposits and ptosis surgery was required in all patients in this series.
眼睑结膜淀粉样变是一种极为罕见的疾病，可导致慢性不适并需要多次手术。
对来自摩尔菲尔德眼科医院的4例患者进行回顾性研究，以评估其临床特征及手术治疗效果。
3例患者有持续性眼部刺激症状，因复发性淀粉样变需要多次手术。然而，1例患者已随访近30年，症状相对较少，仅需偶尔进行手术干预。所有患者均至少接受过一次减积手术和上睑下垂手术。较严重的临床病程与所存在的淀粉样蛋白类型无关。为尽量减少术后后板瘢痕形成，1例患者成功尝试了复发性睑板结膜淀粉样变的削除术并联合中厚黏膜移植术。
眼睑淀粉样变患者的临床病程可能差异很大。可能的情况下治疗应保守，但手术是治疗的一个重要组成部分，因为本系列所有患者均需要进行淀粉样沉积物减积手术和上睑下垂手术。
